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Cohesion of horny cells during comedo formation. An electron microscope study
The British Journal of Dermatology
|December 1, 1977
Summary
Horny cell cohesion in comedones involves initial loose connections via desmosomes and later tight junctions. Membrane coating granule numbers decreased during this process.
Area of Science:
- Dermatology
- Cell Biology
- Histology
Background:
- Comedones are a key feature of acne vulgaris.
- Understanding horny cell cohesion is crucial for developing acne treatments.
Purpose of the Study:
- To investigate the mechanisms of horny cell cohesion in experimentally induced comedones.
- To identify the cellular structures involved in maintaining comedonal plug integrity.
Main Methods:
- Experimentally induced comedones in rabbit external ear canals.
- Electron microscopy to examine cell-cell junctions and cellular structures.
Main Results:
- Horny cell cohesion initially mediated by desmosomes and desmosomal bodies, providing loose adhesion.
- Tight junctions contributed to tighter cell binding in later stages.
- Observed a progressive reduction in membrane coating granules.
Conclusions:
- Two distinct mechanisms contribute to horny cell cohesion in comedones.
- Desmosomes play an early role, followed by tight junctions.
- Decreased membrane coating granules may impact intercellular adhesion in comedones.
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