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Apolipoprotein E polymorphism and coronary heart disease
T F Ashavaid1, Seema P Todur, K G Nair
1Research Laboratories, PD Hinduja Hospital and Medical Research Centre, Veer Savarkar Marg, Mahim, Mumbai 400 016.
The Journal of the Association of Physicians of India
|December 4, 2003
Summary
Apolipoprotein E (apo E) gene variations influence lipid levels, potentially impacting coronary heart disease (CHD) risk. Further research is needed to confirm apo E as a genetic marker for cardiovascular risk assessment in Indian families.
Area of Science:
- Genetics
- Cardiovascular Science
- Biochemistry
Background:
- Apolipoprotein E (apo E) is crucial for lipid transport, with genetic variations (alleles epsilon2, epsilon3, epsilon4) affecting receptor binding and influencing lipid profiles.
- Apo E polymorphism has been linked to altered triglyceride and cholesterol levels, key factors in cardiovascular health.
Purpose of the Study:
- To investigate the role of apolipoprotein E gene polymorphism as a potential genetic marker for coronary heart disease (CHD) risk.
- To assess the utility of apo E genotyping in evaluating cardiovascular risk profiles within families, particularly in the context of rising CHD incidence.
Main Methods:
- Analysis of apolipoprotein E gene polymorphism and its association with lipid profiles.
- Review of existing literature on apo E polymorphism and its link to coronary heart disease.
Main Results:
- Apo E gene exhibits polymorphism with alleles epsilon2, epsilon3, and epsilon4, influencing lipid metabolism.
- The epsilon2 allele is associated with higher triglyceride levels, while the epsilon4 allele is linked to increased cholesterol levels.
Conclusions:
- Apolipoprotein E gene polymorphism plays a role in lipid regulation and may influence cardiovascular risk.
- Further studies are warranted to establish apo E as a reliable genetic marker for cardiovascular risk assessment in diverse populations, including Indians.