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Association between genetic loci linked to HDL-C levels and Indian patients with CAD: a pilot study

Ashley Stanley1, C K Ponde2, R M Rajani2

  • 1Research Laboratories , P. D. Hinduja Hospital & Medical Research Centre , Mumbai , India.

Heart Asia
|January 27, 2017
PubMed

Insights

Genetic variants influencing high-density lipoprotein cholesterol (HDL-C) were not significantly associated with coronary artery disease (CAD) risk in this pilot study. However, four variants confirmed their impact on HDL-C levels.

Area of Science:

  • Cardiovascular Genetics
  • Metabolic Disease Research

Background:

  • High-density lipoprotein cholesterol (HDL-C) plays a crucial role in reverse cholesterol transport.
  • Genetic factors influencing HDL-C levels are potential contributors to coronary artery disease (CAD).

Purpose of the Study:

  • To investigate the association between genetic loci linked to HDL-C levels and the risk of developing CAD.
  • To validate previously identified HDL-C-associated variants in a CAD patient cohort.

Main Methods:

  • Pilot case-control study with 150 CAD cases and 150 non-CAD controls.
  • Genotyping using Illumina's Human Cardio-Metabo BeadChip with 3112 HDL-C variants.
  • Statistical analysis to identify significant associations between variants and CAD status.

Main Results:

  • An initial analysis revealed 36 variants in 16 genes associated with CAD (p<0.05).
  • No variants remained statistically significant after correction for multiple testing.
  • Four variants (rs11039159, rs749067 in MADD; rs367070 in LILRA3; rs330921 in PPP1R3B) showed modest association with HDL-C levels.

Conclusions:

  • Genetic loci associated with HDL-C levels, as examined in this study, do not appear to be significant risk factors for CAD.
  • The study successfully replicated the association of four specific variants with HDL-C levels.
Abstract

Keywords:
CORONARY ARTERY DISEASE

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