Impact of Sacubitril/Valsartan in Improving Home Time for Patients With Heart Failure

Home time, defined as time spent by the patient alive and out of any healthcare institution, is an important patient-centric outcome for patients with cardiovascular disease. Home time is recognized as a crucial measure of recovery post cardiovascular events but has not been extensively studied in heart failure (HF) patients, especially in India. HF in India is rapidly growing at an epidemic scale and hence the focus on improving home time in HF patients highlights the need for precise, patient-centered care strategies. Current literature lacks detailed descriptions of hospital-level patterns and predictors of home time in contemporary HF populations, which hinders tailored approaches to optimize outcomes like functional status and health-related quality of life along with reduced hospitalization and mortality risks. Literature is abundant with clinical evidence on the benefits of guideline-directed medical therapy (GDMT), especially angiotensin receptor neprilysin inhibitor (ARNI) therapy, in HF management. All major guidelines highly recommend its initiation for reducing morbidity and mortality in patients with chronic symptomatic HF with reduced ejection fraction. Studies indicate that sacubitril/valsartan, the first in class of ARNI, improves the quality of life and functional outcomes, along with reduced HF-related hospitalizations and cardiovascular deaths. Its unique mechanism of action, combining neprilysin inhibition and angiotensin receptor blockade, targets multiple pathways of HF pathophysiology, leading to improved cardiac function and remodeling. These benefits are pivotal in supporting patients' ability to maintain an active lifestyle outside of healthcare settings. Despite its demonstrated benefits, sacubitril/valsartan is underutilized. Integrating sacubitril/valsartan more optimally into clinical practice could significantly alleviate the overall burden of HF by addressing key determinants of home time and improving patient outcomes post discharge.