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Differentiation of cerebral tumors using multi-section echo planar MR perfusion imaging
Christoph Preul1, Bernd Kühn, Erhard W Lang
1Klinik für Diagnostische Radiologie, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. preul@cns.mpg.de
European Journal of Radiology
|December 4, 2003
Summary
Magnetic resonance (MR) perfusion imaging effectively differentiates high-grade astrocytomas. The calculated regional cerebral blood volume (rCBV) index shows significant differences between grade III astrocytomas and glioblastomas, aiding diagnosis.
Area of Science:
- Neuroimaging
- Oncology
- Radiology
Background:
- Differentiating between astrocytoma grades (II, III) and glioblastomas is crucial for treatment planning.
- Conventional MRI may not always provide sufficient detail for accurate tumor grading.
Purpose of the Study:
- To evaluate the efficacy of magnetic resonance (MR) perfusion imaging in distinguishing between astrocytoma grades II, III, and glioblastomas.
- To assess the diagnostic performance of the regional cerebral blood volume (rCBV) index.
Main Methods:
- Prospective study involving 33 patients with suspected primary cerebral tumors.
- Multi-section Echo Planar MR perfusion imaging was performed.
- Regional cerebral blood volume (rCBV) index was calculated and correlated with histological tumor classification.
Main Results:
- The rCBV index was significantly different across tumor grades: 1.2+/-0.8 for grade II astrocytomas, 4.0+/-1.2 for grade III astrocytomas, and 10.3+/-3.3 for glioblastomas.
- A highly significant difference (P<0.001) was observed between grade III astrocytomas and glioblastomas.
- MR perfusion imaging provided insights into intratumoral spatial heterogeneities.
Conclusions:
- The rCBV index derived from MR perfusion imaging can differentiate grade III astrocytomas from glioblastomas.
- MR perfusion imaging serves as a valuable tool to augment conventional MRI in tumor diagnosis.
- This technique may also be beneficial for monitoring treatment response.