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[Cardiovascular consequences of obesity associated with arterial hypertension]
1Service de Médecine et Nutrition, Hôtel-Dieu de Paris.
Insights
Obesity and hypertension significantly increase cardiovascular risk, often linked to metabolic issues like insulin resistance. Managing blood pressure and weight can help reverse heart changes and prevent complications.
Area of Science:
- Cardiology
- Metabolic Syndrome
Context:
- Hypertensive obese individuals face elevated cardiovascular risks.
- Abdominal obesity is frequently linked to hypertriglyceridemia and insulin-resistant diabetes.
Purpose:
- To explore the link between obesity, hypertension, and cardiovascular complications.
- To highlight the role of insulin resistance in this association.
Summary:
- Obesity-hypertension is characterized by cardiac hyperdynamics and hypervolemia, leading to left ventricular hypertrophy and dilatation.
- Insulin resistance and hyperinsulinemia are key factors in the obesity-hypertension association and its complications.
- Effective management of arterial pressure and weight is crucial for reversing left ventricular hypertrophy.
Impact:
- Suggests that controlling hypertension and obesity can lead to regression of left ventricular hypertrophy.
- Emphasizes the need for simultaneous treatment of metabolic abnormalities (carbohydrate and lipid) to prevent cardiovascular complications.
Abstract:
Hypertensive obese subjects run an increased cardiovascular risk. Their predominantly abdominal obesity is often associated with hypertriglyceridaemia and insulin-resistant diabetes, and their cardiovascular status is characterized by cardiac hyperdynamics and hypervolaemia responsible for left ventricular hypertrophy and dilatation. Insulin resistance and subsequent hyperinsulinaemia are thought to explain the obesity-hypertension association, the cardiovascular effects observed and the metabolic and cardiovascular complications which might result from this situation. Successful control of both arterial pressure and overweight should contribute to regression of the left ventricular hypertrophy. Simultaneous treatment of abnormalities in carbohydrate and lipid metabolism is also necessary to prevent cardiovascular complications.