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Leukemias and lymphomas in children.
R C Ribeiro1, R Krance, N M Marina
1Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Primary Care
|December 1, 1992
Summary
Childhood leukemias and lymphomas are diverse cancers. While many lymphoid neoplasms are curable, new acute nonlymphoblastic leukemia therapies are needed to improve outcomes.
Area of Science:
- Pediatric oncology
- Hematologic malignancies
Background:
- Leukemias and lymphomas are the most common pediatric neoplasms.
- These cancers are a heterogeneous group with varied features.
- Current treatments are effective for most lymphoid neoplasms.
Purpose of the Study:
- To review the clinical and biologic characteristics of childhood leukemias and lymphomas.
- To discuss current and needed treatment modalities for these diseases.
Main Methods:
- Review of clinical, morphologic, immunologic, cytogenetic, and molecular data.
- Analysis of treatment approaches for lymphoid neoplasms and acute nonlymphoblastic leukemias.
Main Results:
- Childhood lymphoid neoplasms show diverse characteristics.
- Most lymphoid neoplasms are curable with modern therapy.
- Improved treatment strategies are required for acute nonlymphoblastic leukemias.
Conclusions:
- Understanding the heterogeneity of childhood leukemias and lymphomas is crucial.
- Advancements in therapy are essential for improving outcomes, particularly for acute nonlymphoblastic leukemias.