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HCV prevalence in Hodgkin and non-Hodgkin lymphoma cases

Necati Yenice1, Fatih Güllük, Nurten Arican

  • 1Department of Internal Medicine 3rd Section, SSK Okmeydani Training Hospital, Istanbul, Turkey. netyayincilik@turk.net

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
|December 5, 2003
PubMed

Insights

Hepatitis C virus (HCV) is linked to B-cell non-Hodgkin lymphoma, but not Hodgkin lymphoma. This study found higher HCV positivity in B-cell non-Hodgkin lymphoma patients compared to controls.

Area of Science:

  • Virology
  • Oncology
  • Hematology

Background:

  • Hepatitis C virus (HCV) infection is a global health concern.
  • Lymphoproliferative diseases encompass a range of B-cell malignancies.
  • The etiological link between HCV and specific lymphomas requires further investigation.

Purpose of the Study:

  • To investigate the association between hepatitis C virus (HCV) infection and B-cell lymphoproliferative diseases.
  • To determine if HCV positivity differs between patients with B-cell non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) compared to a healthy control group.

Main Methods:

  • Case-control study design.
  • Inclusion of 84 B-cell NHL patients, 50 HL patients, and 100 healthy blood donors.
  • HCV antibody testing (anti-HCV) performed on all participants.

Main Results:

  • Anti-HCV positivity was significantly higher in B-cell NHL patients (7.1%) versus controls (1%, p<0.05).
  • Anti-HCV positivity in HL patients (2%) was comparable to the control group (1%, p<0.05).

Conclusions:

  • Hepatitis C virus (HCV) may contribute to the pathogenesis of B-cell non-Hodgkin lymphoma.
  • The findings do not support a role for HCV in the development of Hodgkin lymphoma.
Abstract

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