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Association of Cirrhosis and Cardiomyopathy

Burcu Sezgin1, Cigdem Cindoglu2, Ahmet Uyanikoglu3

  • 1Department of Internal Medicine, Sanliurfa Education Research Hospital, Sanliurfa, Turkey.

Euroasian Journal of Hepato-Gastroenterology
|January 29, 2020
PubMed

Insights

Elevated pro-BNP levels and prolonged QTc intervals are associated with cirrhotic cardiomyopathy in patients with cirrhosis. These biomarkers indicate a link between the severity of liver disease and cardiac dysfunction.

Area of Science:

  • Cardiology
  • Hepatology
  • Biomarkers

Background:

  • Cirrhotic cardiomyopathy is a common complication in patients with liver cirrhosis.
  • Early diagnosis and identification of cirrhotic cardiomyopathy are crucial for patient management.

Purpose of the Study:

  • To investigate the association of N-terminal pro-B-type natriuretic peptide (pro-BNP), troponin-I, electrocardiography (ECG), and echocardiography (ECHO) in diagnosing cirrhotic cardiomyopathy.
  • To identify potential biomarkers for cirrhotic cardiomyopathy in cirrhotic patients.

Main Methods:

  • Patients were categorized into compensated cirrhotic (n=30), decompensated cirrhotic (n=30), and control (n=30) groups.
  • ECHO, ECG, troponin-I, and pro-BNP levels were analyzed for all participants.

Main Results:

  • A significant increase in QTc interval was observed in compensated cirrhotic patients compared to controls (p <0.05).
  • Pro-BNP levels were significantly higher in compensated cirrhotic patients versus controls (p <0.05).
  • Pro-BNP levels were significantly elevated in decompensated cirrhotic patients compared to both compensated cirrhotic patients and controls (p <0.001).

Conclusions:

  • Increased pro-BNP levels correlate with the severity of liver disease in cirrhotic patients.
  • Prolongation of the QTc interval and elevated pro-BNP levels support their association with cardiomyopathy in cirrhosis.
Abstract

Keywords:
CardiomyopathyCirrhosisPro-BNPQT prolongationTroponin-I

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