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Related Experiment Videos

Nimesulide-induced fulminant hepatitis.

Orhan Ozgür1, Arif Hacihasanoğlu, S Sami Karti

  • 1Division of Gastroenterology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey. ozgur@ktu.edu.tr

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
|December 5, 2003
PubMed
Summary

Nimesulide, a common medication, can rapidly cause severe liver injury (fulminant hepatitis) within days of use. Close monitoring of liver enzymes is crucial for early detection and management in patients taking nimesulide.

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Area of Science:

  • Hepatology
  • Pharmacology
  • Toxicology

Background:

  • Drug-induced liver injury (DILI) is a significant clinical concern.
  • Nimesulide, a non-steroidal anti-inflammatory drug (NSAID), is widely used for pain and inflammation.
  • Fulminant hepatitis is a rare but life-threatening form of liver failure.

Observation:

  • An 18-year-old male presented with jaundice, confusion, and abdominal distension after three days of oral nimesulide use.
  • Clinical and laboratory data strongly suggested nimesulide-induced fulminant hepatitis, excluding other causes.
  • The patient recovered fully after discontinuing nimesulide and receiving supportive care.

Findings:

  • This case highlights a rapid onset of nimesulide-induced fulminant hepatitis, occurring within the first few days of administration.

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  • The patient's rapid recovery upon drug cessation underscores the etiological role of nimesulide.
  • This presentation differs from previously reported cases in the literature regarding the timeline of adverse events.

    • Implications:

    • Healthcare providers should consider nimesulide as a potential cause of acute liver failure, even with short-term use.
    • Frequent monitoring of serum transaminases is recommended from the first week of nimesulide treatment.
    • Early detection and intervention are critical for managing nimesulide-induced hepatotoxicity and improving patient outcomes.