[Glanders--an eradicable disease--or a threat?]

Area of Science:

• Veterinary Microbiology
• Zoonotic Diseases
• Infectious Disease Epidemiology

Context:

• Glanders (malleus) is a significant equid disease with zoonotic potential, historically prevalent but not globally eradicated.
• Recent cases reported in India, Iraq, Mongolia, China, and South America highlight its continued international relevance.
• Occupational infections in laboratory personnel underscore the persistent risk associated with Burkholderia mallei.

Purpose:

• To provide an overview of the current status and ongoing challenges of glanders.
• To highlight the etiological agent, Burkholderia mallei, and its historical nomenclature.
• To emphasize the need for continued research into vaccine development and antibiotic therapies for glanders.

Summary:

• Glanders, caused by Burkholderia mallei, affects equids and can transmit to humans.
• Despite its historical context, glanders persists globally, with recent cases and laboratory-associated infections reported.
• Current research priorities include developing a vaccine and effective antibiotic treatments for glanders.

Impact:

• Informs ongoing research efforts for glanders prevention and treatment.
• Raises awareness of glanders as a persistent zoonotic threat.
• Contributes to the understanding of Burkholderia mallei epidemiology and control strategies.