Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

235
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
235
State Space Representation01:27

State Space Representation

472
The frequency-domain technique, commonly used in analyzing and designing feedback control systems, is effective for linear, time-invariant systems. However, it falls short when dealing with nonlinear, time-varying, and multiple-input multiple-output systems. The time-domain or state-space approach addresses these limitations by utilizing state variables to construct simultaneous, first-order differential equations, known as state equations, for an nth-order system.
Consider an RLC circuit, a...
472
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

273
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
273
Multi-input and Multi-variable systems01:22

Multi-input and Multi-variable systems

335
Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence of...
335
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

205
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
205
Fast Decoupled and DC Powerflow01:24

Fast Decoupled and DC Powerflow

675
The fast decoupled power flow method addresses contingencies in power system operations, such as generator outages or transmission line failures. This method provides quick power flow solutions, essential for real-time system adjustments. Fast decoupled power flow algorithms simplify the Jacobian matrix by neglecting certain elements, leading to two sets of decoupled equations:
675

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-specific regulation of angiogenin in Alzheimer's disease.

Molecular psychiatry·2026
Same author

Real-time transcriptomic profiling in distinct experimental conditions.

eLife·2026
Same author

Mapping human pre-rRNA processing and modification at single nucleotide resolution using long read nanopore sequencing.

Nature communications·2026
Same author

Dynamic allele usage of X-linked genes ameliorates neurodevelopmental disease phenotypes in brain organoids.

Nature communications·2026
Same author

Direct RNA sequencing enables improved transcriptome assessment and tracking of RNA modifications for medical applications.

Nucleic acids research·2025
Same author

ModiDeC: a multi-RNA modification classifier for direct nanopore sequencing.

Nucleic acids research·2025
Same journal

Taphonomic analysis at Liang Bua reveals the behavioral and technological capabilities of <i>Homo floresiensis</i>.

Science advances·2026
Same journal

Targeting granule initiation and amyloplast structure to create giant starch granules in wheat.

Science advances·2026
Same journal

A meta-analysis of carbon losses and gains from tropical moist forest degradation and regeneration.

Science advances·2026
Same journal

Ancient DNA reveals elite dynastic rule among Iron Age Eurasian Steppe nomads.

Science advances·2026
Same journal

Targeting astrocytic Dp71 attenuates BBB disruption after traumatic brain injury through WTAP-associated m<sup>6</sup>A regulation of MMP2.

Science advances·2026
Same journal

Pancreatic α cells are required for nutrient homeostasis by regulating dynamic β cell networks in islets.

Science advances·2026
See all related articles

Related Experiment Video

Updated: Dec 28, 2025

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K

Low-cost scalable discretization, prediction, and feature selection for complex systems.

S Gerber1, L Pospisil2, M Navandar1

  • 1Center of Computational Sciences, Johannes-Gutenberg-University of Mainz, PhysMat/Staudingerweg 9, 55128 Mainz, Germany.

Science Advances
|February 18, 2020
PubMed
Summary
This summary is machine-generated.

A new scalable probabilistic approximation (SPA) algorithm offers improved quality and lower cost for discretizing complex systems. This data-driven approach enhances feature selection and prediction accuracy, outperforming traditional methods.

More Related Videos

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

1.2K
Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
20:24

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study

Published on: January 31, 2014

17.0K

Related Experiment Videos

Last Updated: Dec 28, 2025

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

1.2K
Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
20:24

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study

Published on: January 31, 2014

17.0K

Area of Science:

  • Computational modeling
  • Data science
  • Machine learning

Background:

  • Discretization is essential for modeling complex systems.
  • Existing methods like K-means clustering have limitations in quality, scalability, and cost.
  • There is a need for efficient and accurate discretization techniques.

Purpose of the Study:

  • To introduce a novel scalable probabilistic approximation (SPA) algorithm.
  • To enable simultaneous data-driven optimal discretization, feature selection, and prediction.
  • To demonstrate the algorithm's efficiency and performance improvements over existing methods.

Main Methods:

  • Development of a low-cost, high-quality scalable probabilistic approximation (SPA) algorithm.
  • Mathematical proofs of optimality, parallel efficiency, and linear scalability.
  • Cross-validated applications to large-scale data classification and prediction tasks.

Main Results:

  • SPA achieves simultaneous optimal discretization, feature selection, and prediction.
  • The algorithm demonstrates linear scalability of iteration cost and parallel efficiency.
  • Significant cost and performance improvements were observed in cross-validated applications.
  • Example: Next-day European surface temperature predictions with 0.75°C mean error on a PC.

Conclusions:

  • SPA offers a superior alternative to conventional discretization methods.
  • The algorithm provides substantial cost reductions (5-6 orders of magnitude) and error improvements (~40%).
  • SPA enables highly accurate predictions for complex systems, even on standard hardware.