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Related Experiment Videos

Homocysteine increases during endurance exercise.

Markus Herrmann1, Heike Schorr, Rima Obeid

  • 1Department of Clinical Chemistry/Central Laboratory, University Hospital of Saarland, Homburg/Saar, Germany.

Clinical Chemistry and Laboratory Medicine
|December 6, 2003
PubMed
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Acute endurance exercise, particularly marathon running, significantly elevates homocysteine (Hcy) levels in athletes. This increase is linked to exercise duration and intensity, with some athletes showing hyperhomocysteinemia and low B-vitamin levels.

Area of Science:

  • Exercise Physiology
  • Biochemistry
  • Cardiovascular Health

Background:

  • Hyperhomocysteinemia is a recognized risk factor for cardiovascular and other diseases.
  • While B-vitamins are known homocysteine modulators, the impact of exercise on homocysteine levels remains under-investigated.

Purpose of the Study:

  • To investigate the acute effects of three distinct endurance exercise modalities on serum homocysteine (Hcy) levels.
  • To explore potential correlations between exercise type, duration, intensity, and changes in Hcy.

Main Methods:

  • Serum Hcy was measured in 100 recreational athletes before, and 15 minutes and 3 hours after participating in a marathon, a 100 km run, or a 120 km mountain bike race.
  • Folate and vitamin B12 levels were determined in athletes with pre-race Hcy exceeding 12 micromol/l.

Related Experiment Videos

  • Statistical analysis was performed to assess changes in Hcy and their relationship with exercise parameters and nutrient status.

    • Main Results:

    • Marathon running induced a significant 64% increase in serum Hcy, while 100 km running and 120 km mountain biking showed no significant changes.
    • Post-race Hcy levels peaked at 15 minutes and remained elevated at 3 hours, with the magnitude of change negatively correlating with running time.
    • Approximately 25% of athletes exhibited pre-race hyperhomocysteinemia, associated with lower folate and vitamin B12 levels.

    Conclusions:

    • Acute endurance exercise, especially prolonged running, can significantly increase serum Hcy levels.
    • The exercise-induced Hcy elevation appears dependent on the discipline, duration, and intensity of the physical activity.
    • Recreational endurance athletes may present with hyperhomocysteinemia linked to suboptimal B-vitamin status.