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Reversible dilated cardiomyopathy related to amphotericin B therapy
Patrick J Danaher1, Michael K Cao, Gregory M Anstead
1Department of Infectious Diseases, David Grant USAF Medical Center, Travis AFB, CA 94535, USA. patrick.danaher@60mdg.travis.af.mil
The Journal of Antimicrobial Chemotherapy
|December 6, 2003
Abstract:
We describe a patient who developed dilated cardiomyopathy and clinical congestive heart failure after 2 months of therapy with amphotericin B (AmB) for disseminated coccidioidomycosis. His echocardiographic abnormalities and heart failure resolved after posaconazole was substituted for AmB. It is important to recognize the rare and potentially reversible toxicity of AmB.