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Related Experiment Videos

Different roles for orbitofrontal cortex and basolateral amygdala in a reinforcer devaluation task.

Charles L Pickens1, Michael P Saddoris, Barry Setlow

  • 1Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|December 6, 2003
PubMed
Summary

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The orbitofrontal cortex (OFC) is essential for using learned outcome values to guide behavior, while the basolateral amygdala (BLA) is not required for this post-learning process.

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Cognitive Neuroscience

Background:

  • The orbitofrontal cortex (OFC) and basolateral amygdala (BLA) are implicated in goal-directed behavior.
  • Evidence suggests the BLA acquires cue-outcome associations, and the OFC uses these associations to guide behavior.

Purpose of the Study:

  • To investigate the distinct roles of the OFC and BLA in utilizing learned outcome representations to guide behavior.
  • To test the hypothesis that the BLA acquires associations and the OFC uses them.

Main Methods:

  • Utilized a reinforcer devaluation paradigm in rats.
  • Lesioned the OFC or BLA either before or after conditioning a light cue with a food outcome.
  • Assessed conditioned responding to the cue after devaluing the food outcome.

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Main Results:

  • OFC lesions after conditioning impaired behavioral adjustments to reinforcer devaluation.
  • BLA lesions after conditioning did not affect sensitivity to reinforcer devaluation.
  • Lesions before training impaired devaluation effects for both OFC and BLA.

Conclusions:

  • The OFC is critical for using learned outcome values to guide behavior, including updating and expressing this information.
  • The BLA is involved in forming cue-outcome associations but not in maintaining or expressing their current value.
  • These findings highlight distinct roles for the OFC and BLA in goal-directed performance.