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Measurement of 18F-FDG concentrations in blood samples: comparison of direct calibration and standard solution
Henri N J M Greuter1, Ronald Boellaard, Arthur van Lingen
1PET Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. HNJM.Greuter@VUmc.NL
Objective:
The purpose of this study was to compare the accuracy and reliability of 2 well counter methods for measuring the activity concentration of (18)F-FDG in blood samples.
Methods:
Three to 5 blood samples from 154 patient studies were weighed and measured in a well counter. The (18)F-FDG activity concentration was derived using, first, a direct calibration factor to convert measured well counter readings into activity concentration and, second, a comparison of measured counts with those of a specified standard solution.
Results:
The ratio between the activity concentration results of the 2 methods was 0.996 +/- 0.033, indicating that the methods provided equal results.
Conclusion:
Because the standard solution method is more prone to human error, less reproducible, and more labor intensive, preference should be given to the direct calibration method.
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