Related Experiment Video

Updated: Aug 29, 2026

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

Risk factors for fatal subarachnoid hemorrhage: the Japan Collaborative Cohort Study

Shigeki Yamada1, Akio Koizumi, Hiroyasu Iso

  • 1Dept of Health and Environmental Sciences, Graduate School of Medicine Kyoto University, Konoe-cho, Yoshida, Sakyo-ku, Kyoto, 606-8501, Japan.

Stroke
|December 6, 2003
PubMed

Insights

A history of blood transfusion emerged as a significant independent risk factor for subarachnoid hemorrhage (SAH) mortality in men. Further research is needed to understand this association between SAH and blood transfusions.

Area of Science:

  • Epidemiology
  • Public Health
  • Neurology

Background:

  • Subarachnoid hemorrhage (SAH) is a critical neurological condition with significant mortality.
  • Identifying modifiable and non-modifiable risk factors is crucial for prevention and management.

Purpose of the Study:

  • To identify risk factors associated with mortality from subarachnoid hemorrhage (SAH).
  • To utilize data from the Japan Collaborative Cohort (JACC) Study for a population-based prospective analysis.

Main Methods:

  • Analysis of 109,293 participants (aged 40-79) from the JACC Study, followed from 1988-1999.
  • Cox proportional hazards regression models were used for age-adjusted univariate and multivariate analyses.
  • Sex-stratified and sex-specific analyses were conducted to identify risk factors for SAH mortality.

Main Results:

  • 244 deaths from SAH were recorded during over one million person-years of follow-up.
  • Univariate analysis identified salty food preference, blood transfusion history, hypertension, family history of stroke, smoking, heavy alcohol use, and low BMI as associated with SAH mortality.
  • Multivariable analysis revealed a history of blood transfusion as an independent significant risk factor for SAH mortality in men (HR=4.2).

Conclusions:

  • A history of blood transfusion is an independent risk factor for subarachnoid hemorrhage mortality.
  • The observed association between SAH and blood transfusion necessitates further investigation.
Abstract

More Related Videos

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

Related Concept Videos

Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...