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Published on: August 11, 2023
[Study of midazolam for premedication in oral and maxillofacial surgery]
Hong Jiang1, Ying Zhu, Xu Wang
1Department of Anesthesiology, Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
Objective:
To study the effects of midazolam for premedication in oral-maxillofacial surgery.
Methods:
60 patients were selected and divided into 3 groups equally with 20 cases in each group. Different drugs were used for premedication. Group received midazolam 0.06 mg/kg, group received diazepam 0.12 mg/kg, group received luminal 3 mg/kg, Intramuscular injections of drugs were finished before 30 minutes of anesthesia. The sedative and anxiolytic effects, the changes of circulation and respiration and the side effects were evaluated.
Results:
In group, BIS (bispectral analysis of electroencephalogram) decreased obviously and Ramsay score increased significantly 5 minutes after drug administration, AVAT(Anxiety visual analog test) and SAI(State anxiety inventory) decreased obviously 30 minutes after administration drug (P < 0.05). But no significant changes in the other groups (P > 0.05). There were no remarkable changes of circulation and respiration in the three groups. No severe side effects were observed after premedication.
Conclusion:
The premedication of using midazolam has good sedative and anxiolytic effects and few side effects.
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