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ACE genotype and physical training effects: a randomized study among elderly Danes
Henrik Frederiksen1, Lise Bathum, Charlotte Worm
1Institute of Public Health, Epidemiology, University of Southern Denmark, Odense, Denmark. hfrederiksen@health.sdu.dk
Aging Clinical and Experimental Research
|December 10, 2003
Summary
The Angiotensin Converting Enzyme (ACE) genotype does not appear to influence physical functioning or its changes in the elderly. This study found no association between ACE genotype and physical performance in older adults.
Area of Science:
- Gerontology
- Exercise Physiology
- Human Genetics
Background:
- Physical functioning (PF) in aging is influenced by genetic factors.
- The Angiotensin Converting Enzyme (ACE) insertion/deletion (I/D) polymorphism is linked to PF and trainability.
- Previous ACE genotype studies focused on younger, physically fit individuals.
Purpose of the Study:
- To investigate the association between ACE genotype and PF in the elderly.
- To examine if ACE genotype affects PF levels, trainability, or rate-of-change in older adults.
Main Methods:
- Utilized data from 4 randomized training studies involving 203 elderly Danes.
- Assessed PF through self-report, maximal oxygen uptake, muscle strength, walking speed, and body composition.
Main Results:
- Training groups showed improved PF compared to control groups.
- No association was found between ACE genotype and pre- or post-training PF levels.
- No association was found between ACE genotype and the change in PF over time.
Conclusions:
- No association was detected between ACE genotype and physical functioning in the elderly.
- The ACE genotype did not influence physical performance or changes in response to training or spontaneous changes in this cohort.