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Maturation of mismatch negativity: a scalp current density analysis
Brett A Martin1, Valerie L Shafer, Mara L Morr
1Albert Einstein College of Medicine, Bronx, New York. martinbr@shu.edu
Ear and Hearing
|December 10, 2003
Summary
Mismatch negativity (MMN) brain responses mature significantly between childhood and adulthood, particularly in frontal regions. These findings suggest that the neural basis for auditory discrimination continues developing past age 11.
Area of Science:
- Neuroscience
- Auditory Neuroscience
- Developmental Neuroscience
Background:
- Auditory evoked potentials offer insights into central auditory processing, crucial for speech and language.
- Mismatch negativity (MMN) is an auditory evoked potential reflecting early automatic auditory change detection.
Purpose of the Study:
- To investigate maturational changes in the scalp topography of mismatch negativity (MMN).
- To utilize scalp current density (SCD) analysis for examining MMN topographical development.
Main Methods:
- Studied children (4-11 years) and adults using auditory evoked potentials.
- Presented standard (1000 Hz) and deviant (1200 Hz) tones while participants watched a silent video.
- Recorded MMN using 32 scalp electrodes and analyzed with SCD.
Main Results:
- Significant developmental changes in MMN topography were observed.
- These changes were prominent over frontal and left lateral scalp sites.
Conclusions:
- MMN generators or their orientation differ between children and adults.
- Neural processes for simple tone discrimination are immature in children up to 11 years old.