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Updated: Aug 7, 2026
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 3, 2013
Androgen receptor antigen density and S-phase fraction in prostate cancer: a pilot study
M Abdel-Wahab1, A Krishan, C Milikowski
1Department of Radiation Oncology, University of Miami, Florida 33136, USA. mwahab@med.miami.edu
Purpose:
To determine whether quantitative flow cytometric androgen receptor density expression (MFC ratio) in prostate cancer was associated with S-phase fraction.
Methods:
Flow cytometry was performed to determine DNA aneuploidy, S-phase fraction, percentage of androgen receptor (AR)-positive cells, and MFC ratio in prostate cancer patients.
Results:
MFC ratio showed distinct clustering. Eight patients had a low MFC ratio of 1.78-2.74, while 10 patients had high MFC ratios between 4.99 and 6.48. The S-phase fraction had average values of 11.05 vs 4.92 in tumors with high vs low MFC ratio (P<0.01).
Conclusion:
S-phase fraction was significantly higher in tumors with high AR density.
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