Related Experiment Video

Updated: Jul 14, 2026

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR
15:16

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

17.2K

Acute rotavirus gastroenteritis in children less than 5 years old: Salient clinical and laboratory features

C H Ding1, A A Wahab2, A Ali3

  • 1Universiti Kebangsaan Malaysia, Faculty of Medicine, Department of Medical Microbiology and Immunology, Kuala Lumpur, Malaysia. dingch@ppukm.ukm.edu.my.

The Malaysian Journal of Pathology
|April 30, 2025
PubMed

Insights

Rotavirus gastroenteritis in children presents with more vomiting and dehydration but less fever and convulsions than non-rotavirus causes. Differentiating features include serum urea and C-reactive protein levels.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Gastroenterology

Background:

  • Rotavirus is a leading cause of gastroenteritis in young children globally.
  • Malaysia experiences significant burden of rotavirus gastroenteritis (RG) in pediatric populations.

Purpose of the Study:

  • To determine the clinical and laboratory features of acute rotavirus gastroenteritis (RG) in children under 5 years old.
  • To differentiate RG from non-rotavirus gastroenteritis (NRG) based on clinical and laboratory findings.

Main Methods:

  • Retrospective study of pediatric patients with acute gastroenteritis.
  • Data collected from electronic medical records and laboratory systems (2015-2022).

Main Results:

  • Rotavirus gastroenteritis (RG) diagnosed in 30.5% of 177 patients.
  • RG associated with higher rates of vomiting (85.2%) and dehydration (64.8%).
  • RG less associated with fever (57.4%) and convulsions (0.0%), with lower CRP and higher serum urea levels compared to NRG.

Conclusions:

  • Clinical presentation (vomiting, dehydration, fever, convulsions) can help distinguish RG from NRG.
  • Serum urea and C-reactive protein (CRP) levels offer further differentiation between RG and NRG.
Abstract

More Related Videos

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

8.5K
Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins11:40

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

Published on: April 17, 2020

8.4K

Related Concept Videos

Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through interaction...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...