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Related Experiment Videos

A paramagnetic CEST agent for imaging glucose by MRI.

Shanrong Zhang1, Robert Trokowski, A Dean Sherry

  • 1The Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9085, USA.

Journal of the American Chemical Society
|December 11, 2003
PubMed
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A novel europium(III) complex with phenyl boronate arms acts as a glucose sensor. This agent enables high-sensitivity MRI imaging of glucose levels in tissues by altering water molecule exchange.

Area of Science:

  • Biomedical Imaging
  • Chemical Biology
  • Materials Science

Background:

  • Developing sensitive glucose detection methods is crucial for managing diabetes.
  • Current MRI techniques for glucose detection have limitations in sensitivity and specificity.
  • Paramagnetic contrast agents offer potential for enhanced MRI contrast.

Purpose of the Study:

  • To develop a novel europium(III) complex for glucose-responsive MRI.
  • To investigate the glucose binding properties and MRI contrast capabilities of the complex.
  • To assess the potential for in vivo glucose imaging.

Main Methods:

  • Synthesis of a europium(III) complex with a DOTA-tetraamide ligand and phenyl boronate pendent arms.
  • Characterization of glucose binding affinity using association constants.

Related Experiment Videos

  • Evaluation of water exchange dynamics using Magnetic Resonance Imaging (MRI) with chemical exchange saturation transfer (CEST) imaging.
  • Testing the agent's response to physiological glucose concentrations (0-20 mM).

    • Main Results:

    • The europium(III) complex binds glucose reversibly with an association constant of 383 M-1 at pH 7.
    • Glucose binding significantly slows water exchange between the Eu(III)-bound water molecule and bulk water.
    • The agent demonstrates metabolite-responsiveness to glucose within the physiologically relevant range.
    • CEST imaging successfully visualized changes in glucose concentration.

    Conclusions:

    • The developed europium(III) complex functions as a sensitive glucose-responsive MRI contrast agent.
    • This agent utilizes bulk water protons as an 'antenna' for high-sensitivity glucose detection.
    • The findings suggest a promising new avenue for non-invasive glucose monitoring using MRI.