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Updated: Aug 29, 2026
Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
Assisted reproduction in patients with early-stage ovarian malignancies
Michael P Steinkampf1, Sejal P Dharia, Karen Hammond
1Division of Reproductive Endocrinology and Infertility, University of Alabama at Birmingham, Birmingham, Alabama 35249-7333, USA. msteinkampf@uabmc.edu
Objective:
To determine the outcome of women with early-stage ovarian malignancies who subsequently underwent assisted reproductive technologies (ART).
Design:
Retrospective study.
Setting:
Academic assisted reproductive technology program.
Patient(S):
Four infertile women who were previously diagnosed with early-stage ovarian malignancies.
Intervention(S):
Controlled ovulation hyperstimulation, IVF, and/or gamete intrafallopian transfer treatments using clomiphene citrate and/or gonadotropins.
Main Outcome Measure(S):
Development of tumor recurrence and disease-free interval.
Result(S):
All four women remain free of disease for up to 15 years after treatment. Three of the four women achieved pregnancy.
Conclusion(S):
In patients with early-stage ovarian malignancies, conservative therapy followed by ovarian stimulation for assisted reproduction is an acceptable strategy.
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