Transgenes in autoimmunity

M S Lee1, N Sarvetnick

  • 1Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037.

The ability of transgenic mice to express a specific protein in a specific tissue has enabled the mechanisms of self-tolerance and autoimmunity to be elucidated. Further studies, combined with more sophisticated methods of gene targeting, will provide insights into the pathway leading from loss of self-tolerance to autoimmunity.

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