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Updated: Aug 29, 2026

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
Published on: August 26, 2021
[Inpatient cardiac defibrillation: efficacy of bipolar sinusoidal impulse]
V A Vostrikov1, A L Syrkin, P V Kholin
1I. M. Sechenov Moscow Medical Acdemy, ul. Bolshaya Pirogovskaya 2/6, 119881 Moscow, Russia.
Abstract:
Efficacy of external defibrillation of the heart with low energy (=65-195 J) bipolar quasi sinusoidal discharges was studied in 76 patients with induced, primary (overall 70 episodes), and secondary (88 episodes) ventricular fibrillation (VF) and hemodynamically unstable ventricular tachycardia (VT) with or without acute myocardial infarction. Maximal effective discharge energy used for termination of induced and primary VF or VT was 90 J in 10 of 66 patients (15%) ). Meanwhile discharge energy 165-193 J was required for termination of secondary VF in 6 of 34 patients (18%). Overall efficacy of cardiac defibrillation with discharge energies =115 and =193 J was 92 and 100%, respectively. Success of resuscitation in patients with prolonged (2-28 min) primary and secondary VF was 82 and 68%, respectively. VF duration before first discharge (0,5-8 min) did not affect significantly magnitude of effective energy in interval between 90 and 193 J. However lower energy discharges were less effective when duration of fibrillation exceeded 30 sec.
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