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Updated: Aug 29, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
Published on: April 14, 2016
[Perspectives of the direct search for analgesics: new "targets" (lecture)]
Abstract:
Essential distinctions in the neurophysiologic and neurochemical mechanisms related with the shaping of pain syndromes presuppose the administration of different-action analgetics in coping with such syndromes. Data, obtained recently in studying the fundamental mechanisms of nociception and analgesia, denote a variety of new "targets" for potential analgetics, i.e. cannabinoid receptors, NMDA-receptors of subtype NR2B, kainate and metabotropic receptors, central n-cholinergic receptors, vanilloid receptors and purinoceptors, tetrodotoxin-insensitive sodium channel SNS/PN3, calcium channels of N-type and gabapenti-binding protein.
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