Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cdk5: a novel role in learning and memory.

André Fischer1, Farahnaz Sananbenesi, Joachim Spiess

  • 1Laboratory on Cell Biologic Mechanisms of Memory, Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Göttingen, Germany.

Neuro-Signals
|December 16, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hippocampal CA2 modulates trace fear conditioning through circuit-specific control of CA1.

bioRxiv : the preprint server for biology·2026
Same author

In-situ inference of the thermoacoustic properties of an industrial combustion systema).

The Journal of the Acoustical Society of America·2026
Same author

Learning the relationship between operating condition and flame response from acoustic dataa).

The Journal of the Acoustical Society of America·2026
Same author

The epitranscriptomic m6A RNA modification modulates the synapse in ageing and in a mouse model of synucleinopathy.

NPJ Parkinson's disease·2026
Same author

The role of microRNAs in executive functions: a comprehensive review and bioinformatics analysis of human and animal studies.

Molecular psychiatry·2026
Same author

Blood-derived microRNA signatures associated with hippocampal structure and atrophy rate: findings from the Rhineland Study.

Molecular psychiatry·2026
Same journal

A Comprehensive Review of Melatonin as Multi-Pathway Neuroprotectant Against Methamphetamine-Induced Programmed Cell Death: Discovery of the Circadian-Ferroptosis Axis.

Neuro-Signals·2026
Same journal

The Impact of Vitamin D Deficiency on Cognitive and Neuromuscular Functions in Elderly Patients.

Neuro-Signals·2026
Same journal

Tracing the Evolution and Recombination Events of Neurotropic Arenaviridae Viruses: a Bioinformatics Approach.

Neuro-Signals·2025
Same journal

Peripheral Inflammation as a Biomarker of Disease Activity in Relapsing-Remitting MS.

Neuro-Signals·2025
Same journal

Aberrant Hippocampal Neuroregenerative Plasticity in Schizophrenia: Reactive Neuroblastosis as a Possible Pathocellular Mechanism of Hallucination.

Neuro-Signals·2024
Same journal

A Narrative Review - Therapy Options and Therapy Failure in Retinoblastoma.

Neuro-Signals·2022
See all related articles

Cyclin-dependent kinase 5 (Cdk5) plays a novel role in learning and memory. Its known neurodevelopmental functions may also contribute to synaptic plasticity and memory consolidation in adult brains.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cellular Biology

Background:

  • Learning and memory involve information acquisition, retention, and retrieval, crucial for adaptation.
  • Protein phosphorylation is a key mechanism in synaptic modifications underlying learning and memory.
  • Established signaling pathways include cyclic AMP-dependent protein kinase (PKA), protein kinase C (PKC), and extracellularly regulated protein kinases 1 and 2 (Erk-1/2).

Purpose of the Study:

  • To review recent findings on the role of Cyclin-dependent kinase 5 (Cdk5) in learning and memory.
  • To explore the potential involvement of Cdk5's neurodevelopmental functions in adult synaptic plasticity and memory consolidation.

Main Methods:

  • Review of recent scientific literature and findings.
  • Analysis of molecular mechanisms involving protein kinases and phosphatases.

Related Experiment Videos

  • Investigation of signaling pathways in neuronal cells and subcellular compartments.

    • Main Results:

    • Cyclin-dependent kinase 5 (Cdk5) has emerged as a significant factor in learning and memory processes.
    • Cdk5's established roles in neurodevelopment may extend to synaptic plasticity in the adult central nervous system.
    • Interactions of Cdk5 with cytoplasmic and synaptic molecules are implicated in memory consolidation.

    Conclusions:

    • Cdk5 represents a novel signaling pathway involved in learning and memory.
    • The neurodevelopmental functions of Cdk5 are potentially repurposed for synaptic plasticity and memory consolidation in adult organisms.
    • Further research into Cdk5's molecular interactions can elucidate its precise role in memory formation.