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Sweating dysfunction in Parkinson's disease.

Lesley Swinn1, Anette Schrag, Ramchandran Viswanathan

  • 1National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.

Movement Disorders : Official Journal of the Movement Disorder Society
|December 16, 2003
PubMed
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Sweating disturbances like hyperhidrosis are common in Parkinson's disease (PD), affecting 64% of patients. These symptoms are linked to autonomic dysfunction and motor fluctuations, impacting quality of life.

Area of Science:

  • Neurology
  • Autonomic Dysfunction

Background:

  • Sweating disturbances are a common yet under-recognized issue in Parkinson's disease (PD).
  • Understanding the prevalence and impact of these symptoms is crucial for patient care.

Purpose of the Study:

  • To determine the prevalence and characteristics of sweating disturbances in PD patients.
  • To investigate correlations between sweating issues, clinical features, and quality of life (QoL).

Main Methods:

  • A questionnaire assessing sweating dysfunction was administered to 77 PD outpatients and 40 controls.
  • Quality of Life was measured using PDQ-39 and EQ-5D scales.
  • Clinical assessments included UPDRS and Hoehn and Yahr staging.

Main Results:

Related Experiment Videos

  • 64% of PD patients reported sweating disturbances (hypohidrosis or hyperhidrosis) versus 12.5% of controls.
  • Symptoms were often localized or asymmetric and correlated with autonomic dysfunction, not disease severity.
  • Sweating problems were more frequent during 'off' periods and 'on' periods with dyskinesias.

    • Conclusions:

    • Sweating disturbances are prevalent and distressing in Parkinson's disease.
    • These symptoms are primarily associated with autonomic dysfunction, motor fluctuations ('off' periods), and dyskinesias.
    • While not correlated with overall QoL, sweating issues significantly impact pain dimensions and daily functioning.