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Related Experiment Videos

Pellet coating by air suspension technique using a mini-model coating unit.

M Ganesan1, T K Pal, M Jayakumar

  • 1Department of Pharmaceutical Technology, Jadavpur University, Calcutta-700032, India.

Bollettino Chimico Farmaceutico
|December 18, 2003
PubMed
Summary

A new compact air suspension coating instrument was developed for small-scale pharmaceutical coating. This laboratory model efficiently coats drug particles with high uniformity and reproducibility, ideal for research and sustained drug delivery applications.

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Chemical Engineering

Background:

  • Air suspension coating is a versatile pharmaceutical coating technique for various dosage forms.
  • Existing equipment requires large material quantities (≥1 kg), limiting small-scale research.
  • A need exists for compact, efficient air suspension coaters for gram-scale operations.

Purpose of the Study:

  • To design and evaluate a laboratory-scale, top-spray air suspension coating instrument.
  • To assess the instrument's performance for drug loading and pellet coating.
  • To determine the feasibility of using the instrument for small-quantity pharmaceutical preparations.

Main Methods:

  • Designed and constructed a compact, top-spray air suspension coating instrument.

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  • Evaluated drug loading efficiency using Terbutaline sulphate onto non-pareil pellets (10 g load).
  • Assessed coating uniformity via Scanning Electron Microscopy (SEM) and in vitro drug release studies using Surelease®.

    • Main Results:

    • Achieved approximately 82% drug loading efficiency, demonstrating satisfactory and reproducible performance.
    • SEM confirmed homogenous and uniform coating on drug-loaded pellets.
    • In vitro drug release studies showed minimal deviation (<2.74%) and high reproducibility (95% CI <5%), fitting a first-order kinetic model.

    Conclusions:

    • The designed mini-model air suspension coater is effective for small-scale preparation of coated multiparticulate dosage forms.
    • The instrument offers uniform coating and reproducible drug release, suitable for research and sustained drug delivery.
    • Coating thickness significantly influences drug release rates, highlighting process control importance.