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Angiogenesis inhibitors may regulate adiposity

Liping Liu1, Mohsen Meydani

  • 1Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.

Nutrition Reviews
|December 18, 2003
PubMed

Insights

Obesity is a health concern. Angiogenesis inhibitors, used for tumors, reduced fat tissue in mice by blocking blood supply, suggesting potential for obesity treatment.

Area of Science:

  • Biomedical Science
  • Obesity Research
  • Cancer Biology

Background:

  • Overweight and obesity are significant global health issues.
  • Associated co-morbidities pose complex health challenges.
  • Current weight loss strategies primarily rely on diet and exercise.

Purpose of the Study:

  • To investigate the potential of angiogenesis inhibitors in managing obesity.
  • To explore a novel therapeutic approach for adipose tissue reduction.

Main Methods:

  • Utilized an obese mouse model.
  • Administered angiogenesis inhibitors, typically used for tumor growth inhibition.
  • Assessed the impact on adipose tissue mass and blood supply.

Main Results:

  • Angiogenesis inhibitors significantly reduced adipose tissue mass in the obese mouse model.
  • The mechanism involved the inhibition of blood supply to the adipose tissue.
  • This suggests a potential anti-obesity effect.

Conclusions:

  • Angiogenesis inhibition presents a promising strategy for obesity prevention and treatment.
  • Dietary components with antiangiogenic properties may offer therapeutic benefits.
  • Further research is warranted to translate these findings to human applications.

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