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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
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Nonanoic acid--an experimental irritant

Jan E Wahlberg1, Magnus Lindberg

  • 1National Institute of Working Life, Karolinska Institutet and Stockholm Centre of Public Health, Stockholm, Sweden.

Contact Dermatitis
|December 18, 2003
PubMed

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Nitrous acid is a relatively weak and unstable acid prepared in situ by the reaction of sodium nitrite and cold, dilute hydrochloric acid. In an acidic solution, the nitrous acid undergoes protonation when it loses water to form a nitrosonium ion—an electrophile. Nitrous acid reacts with primary amines to give diazonium salts. The reaction is called diazotization of primary amines.
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