Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Trigeminal responses to laser stimuli.

A Romaniello1, G D Iannetti, A Truini

  • 1Department of Neurological Sciences, University La Sapienza, Viale Università 30, 00185 Rome, Italy.

Neurophysiologie Clinique = Clinical Neurophysiology
|December 18, 2003
PubMed
Summary

Laser evoked potentials (LEPs) from the trigeminal system offer a quick method for assessing facial pain pathways. Abnormal trigeminal LEPs indicate neurological conditions like trigeminal neuralgia and migraine.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trigeminal root dislocation subtends focal demyelination of primary trigeminal afferents in patients with trigeminal neuralgia.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

A Robust Approach to Quantify Nocifensive Blink Reflex Responsiveness.

The European journal of neuroscience·2026
Same author

Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian neurological society.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2025
Same author

Chronic pain: are there effective therapeutic exercises in rehabilitation treatment? A narrative review.

La Clinica terapeutica·2024
Same author

Nerve ultrasound in Friedreich's Ataxia: enlarged nerves as a biomarker of disease severity.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2024
Same author

Predicting value for incomplete recovery in Bell's palsy of facial nerve ultrasound versus nerve conduction study.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2023

Area of Science:

  • Neuroscience
  • Neurophysiology
  • Pain Research

Background:

  • Laser evoked potentials (LEPs) studies traditionally focused on limb stimulation.
  • Trigeminal system LEPs are easier to record due to high facial receptor density and short conduction distances.

Purpose of the Study:

  • To investigate the utility of trigeminal LEPs for assessing orofacial pain syndromes.
  • To explore the diagnostic potential of LEPs in neurological conditions affecting the trigeminal nerve.

Main Methods:

  • Recording LEPs following laser stimulation of the trigeminal nerve territory.
  • Analyzing LEP characteristics in healthy individuals and patients with trigeminal system disorders.
  • Observing reflex responses like the blink reflex and masseter silent period.

Related Experiment Videos

Main Results:

  • Trigeminal LEPs are easily and rapidly obtained, even ultralate potentials related to C-fibre input.
  • Absent or delayed LEPs were observed in trigeminal neuralgia, neuropathies, and brainstem lesions.
  • Enhanced LEPs were noted in migraine patients.
  • High-intensity stimulation elicited blink reflex and masseter silent period.

Conclusions:

  • Trigeminal LEPs provide a valuable neurophysiological tool for evaluating trigeminal nociceptive pathways.
  • LEPs aid in understanding the pathophysiology of orofacial pain syndromes.
  • This method offers new diagnostic opportunities for trigeminal nerve dysfunction.