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Cell-permeable small molecule probes for site-specific labeling of proteins
Dawn S Y Yeo1, Rajavel Srinivasan, Mahesh Uttamchandani
1Department of Biological Sciences, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore.
Chemical Communications (Cambridge, England)
|December 19, 2003
Abstract:
We have successfully synthesized a number of small molecule probes designed for site-specific labeling of N-terminal cysteine-containing proteins expressed in live cells. Their utility for site-specific, covalent modifications of proteins was successfully demonstrated with purified proteins in vitro, and with live bacterial cells in vivo.