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[Antitumor effects of electrothermal and electrochemical therapy on mice with sarcoma180]
1Department of Oral and Maxillofacial Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
Objective:
To explore the anti-tumor effects and the mechanism of a new treatment for Sarcoma180 in mice using both hyperthermia (H) and electrochemical therapy (ECT).
Methods:
A group of mice with Sarcoma180 (1 cm in diameter) were divided randomly into four groups and given different treatments: Control, ECT alone, H alone and electrothermal & electrochemical therapy (ETECT). The volumes of the tumors were calculated everyday after treatment. The tumor tissues were examined morphologically at 0, 6, 24 and 72 hours after treatment.
Results:
The tumors treated with ETECT were completely destroyed, and did not recur within a period of ten days by pathological examination. Results of this group were significantly different with the other groups (P<0.01). However, recurred tumors were found in 6 mice of H group and 5 mice of ECT group, respectively.
Conclusions:
Based on the results obtained, ETECT induced by ETECD (D-device) is an effective way to eliminate cancer. It is capable of completely destroying cancer cells in a short time. The rate of Sarcoma180 inhibition is 100%, and malignant cells can't recur. The research provided theoretical and experimental bases for the treatment of oral cancer by a new approach to treat oral cancer.
