Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ASD: the Alternative Splicing Database.

T A Thanaraj1, Stefan Stamm, Francis Clark

  • 1European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. thanaraj@ebi.ac.uk

Nucleic Acids Research
|December 19, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of isoform switching events linked with esophageal adenocarcinoma patient survival informs novel prognostic and therapeutic targets.

Cell death & disease·2026
Same author

Circular RNAs from the MAPT and TARDBP genes: Novel players in neurodegeneration?

Neurochemistry international·2025
Same author

An oligo walk to identify siRNAs against the circular Tau 12->7 RNA.

bioRxiv : the preprint server for biology·2025
Same author

A prospective pragmatic evaluation of automatic trial matching tools in a molecular tumor board.

NPJ precision oncology·2025
Same author

Translation of circular RNAs.

Nucleic acids research·2024
Same author

Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor.

Molecular metabolism·2024
Same journal

Neurochondrin promotes U5 snRNP maturation by regulating AAR2 release from PRPF8.

Nucleic acids research·2026
Same journal

Elongationless start-stop elements are stress-resilient translation gates that are more repressive than uTranslons.

Nucleic acids research·2026
Same journal

Evolution of the ribosomal exit tunnel through the eyes of the nascent chain.

Nucleic acids research·2026
Same journal

Enhancing the performance and interpretability of epigenetic clocks.

Nucleic acids research·2026
Same journal

FABIAN-variant 2026: improved prediction of the effects of DNA variants on transcription factor binding.

Nucleic acids research·2026
Same journal

Structural and biochemical characterization of Grimontia hollisae thermostable direct hemolysin with DNA reveals first Vibrio hemolysin with nuclease activity.

Nucleic acids research·2026
See all related articles

Alternative splicing generates diverse gene products crucial for development and disease. The Alternative Splicing Database (ASD) now offers curated data on splice events and regulatory mechanisms across nine species.

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Alternative splicing is a key mechanism in mammalian gene expression, producing varied transcript isoforms.
  • Specific splice patterns are often linked to developmental stages, tissue types, or disease states.
  • Systematic data collection and annotation of alternative splicing events are essential.

Purpose of the Study:

  • To present two key products from the Alternative Splicing Database (ASD) consortium.
  • To provide a database of computationally identified alternative splice events.
  • To offer a database of alternatively spliced exons curated from scientific literature.

Main Methods:

  • Computationally delineating alternative splice events from EST/cDNA and genome sequence alignments.

Related Experiment Videos

  • Curating alternatively spliced exons from published scientific literature.
  • Annotating splice events with biological features such as expression states and cross-species conservation.

    • Main Results:

    • Development of a database detailing computationally identified alternative splice events across nine organisms.
    • Creation of a literature-derived database of alternatively spliced exons.
    • Annotation of splice events for biological context, including conservation and expression.

    Conclusions:

    • The ASD provides valuable, curated resources for studying alternative splicing.
    • These databases facilitate research into the biological roles and regulatory mechanisms of splice variants.
    • The ASD web pages serve as a central hub for accessing this critical data.