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Human protein reference database as a discovery resource for proteomics.

Suraj Peri1, J Daniel Navarro, Troels Z Kristiansen

  • 1McKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21287, USA.

Nucleic Acids Research
|December 19, 2003
PubMed
Summary

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This summary is machine-generated.

The Human Protein Reference Database (HPRD) integrates human protein data, including interactions and modifications, aiding biomedical research. This resource provides a unified view of protein information for health and disease studies.

Area of Science:

  • Genomics
  • Proteomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Genomic and proteomic data generation is accelerating.
  • Managing and integrating data from diverse sources is crucial.
  • Existing resources may lack comprehensive human protein information.

Purpose of the Study:

  • To present the Human Protein Reference Database (HPRD) as a comprehensive resource.
  • To facilitate the integration of disparate genomic and proteomic data.
  • To support biomedical discoveries by providing curated protein information.

Main Methods:

  • Manual curation of published literature by expert biologists.
  • Bioinformatics analyses of protein sequences.

Related Experiment Videos

  • Development of a web-based resource utilizing open-source technologies.

    • Main Results:

    • HPRD provides detailed information on human proteins.
    • Data includes protein-protein interactions, post-translational modifications, enzyme-substrate relationships, and disease associations.
    • The database offers an integrated view of protein sequence, structure, function, and networks.

    Conclusions:

    • HPRD serves as a valuable resource for biomedical research.
    • The database aids in understanding protein networks in health and disease.
    • Integrated data facilitates new discoveries in genomics and proteomics.