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Pathbase: a database of mutant mouse pathology.

Paul N Schofield1, Jonathan B L Bard, Catherine Booth

  • 1Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. ps@mole.bio.cam.ac.uk

Nucleic Acids Research
|December 19, 2003
PubMed
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This summary is machine-generated.

Pathbase offers a searchable collection of mouse histology images, detailing normal and abnormal tissues from various genetic modifications. This resource aids researchers in understanding mouse models for disease research.

Area of Science:

  • * Comparative Pathology
  • * Genomics and Bioinformatics
  • * Developmental Biology

Background:

  • * Accurate histological data is crucial for understanding genotype-phenotype correlations in mouse models.
  • * Existing resources often lack comprehensive, high-resolution, and easily searchable image collections of mouse pathology.
  • * The development of specialized databases is essential for advancing research using genetically modified mice.

Purpose of the Study:

  • * To introduce Pathbase, a publicly accessible database of mouse histology images.
  • * To provide a structured and searchable repository for images of normal and abnormal mouse tissues.
  • * To facilitate the study of spontaneous and induced mutations in mouse models.

Main Methods:

  • * Curated collection of high-resolution images of normal and abnormal mouse histology.

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  • * Database structured around a novel ontology of mouse disorders (MPATH).
  • * Searchable through orthogonal ontologies for pathology, developmental stage, anatomy, and gene attributes (GO terms).
  • * Inclusion of controlled vocabularies for genetic manipulation, genotype, and strain information.
  • * Data assessed by pathologists before publication.

    • Main Results:

    • * Pathbase provides publicly accessible, high-resolution downloadable images.
    • * Images cover spontaneous and induced mutations, including transgenesis and chemical mutagenesis.
    • * Includes normal histology and strain-dependent background lesions.
    • * Database is linked to other relevant genetic and anatomical databases.
    • * Features public comment and annotation functionalities.

    Conclusions:

    • * Pathbase serves as a valuable, integrated resource for researchers studying mouse models.
    • * The database enhances the discoverability and utility of mouse histology data.
    • * Facilitates comparative analysis and understanding of genetic manipulation effects on tissue morphology.