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Lipid peroxides in blood from patients with atherosclerosis of coronary and peripheral arteries
H Plachta1, E Bartnikowska, A Obara
1Department of Surgery, Postgraduate Medical Center of Military Medical Academy, Warsaw, Poland.
Insights
Elevated plasma lipid peroxides indicate increased atherosclerosis risk in patients with coronary and peripheral artery disease. Monitoring these levels may aid in managing atherosclerosis.
Area of Science:
- Biochemistry
- Cardiovascular Medicine
- Clinical Chemistry
Background:
- Atherosclerosis is a significant health concern linked to lipid metabolism.
- Lipid peroxidation is implicated in the pathogenesis of atherosclerotic diseases.
Purpose of the Study:
- To investigate the association between plasma lipid peroxide levels and atherosclerosis.
- To compare lipid peroxide concentrations in patients with coronary artery disease (CAD), peripheral artery disease (PAD), and healthy controls.
Main Methods:
- Quantification of plasma lipid peroxides in 300 participants (100 CAD, 100 PAD, 100 controls).
- Analysis of lipid peroxide levels in relation to disease presence, history of myocardial infarction, and PAD severity.
- Correlation analysis with age, total cholesterol, and triglycerides.
Main Results:
- Significantly higher plasma lipid peroxide concentrations were found in patients with atherosclerosis (CAD and PAD) compared to controls.
- No significant difference in lipid peroxides between CAD and PAD patient groups.
- Positive correlation between lipid peroxide levels and PAD severity.
- Age showed a correlation with lipid peroxides, but atherosclerosis patients remained higher than age-matched controls.
- Weak, non-significant correlations observed between lipid peroxides and total cholesterol or triglycerides.
Conclusions:
- Plasma lipid peroxidation is a key factor in atherosclerotic development.
- Elevated plasma lipid peroxides are indicative of atherosclerosis.
- Plasma lipid peroxide measurement offers valuable supplementary data for monitoring patients with atherosclerosis.
Abstract:
Lipid peroxides in plasma were determined in 100 patients with coronary artery disease, in 100 patients with peripheral artery disease and in 100 persons without any clinical symptoms of coronary or peripheral artery disease. The concentrations of lipid peroxides were significantly higher in patients with atherosclerosis (both coronary and peripheral arteries) than in controls. There was no difference between lipid peroxides in patients with coronary and peripheral artery disease. Lipid peroxides in plasma were similar in subgroups of patients with coronary artery disease without a history of myocardial infarct and those who had had myocardial infarct. In subgroups of patients with peripheral artery disease divided according to the severity of peripheral atherosclerosis a positive association between the concentration of lipid peroxides in plasma and the severity of disease was observed. In all groups there was a significant correlation between the age of examined persons and lipid peroxides in plasma; however, the concentration of lipid peroxides in plasma was statistically higher in patients with atherosclerosis than in the control age matched group. The correlation between lipid peroxides and total cholesterol as well as triglycerides were weak and not statistically significant in most of the examined groups. The results of this study provide clinical support for experimental data indicating that peroxidation of lipids is an important factor in the formation of atherosclerotic changes. They also indicate that determination of plasma lipid peroxides may give important supplementary information in monitoring patients with clinical symptoms of atherosclerosis.