[Structure, function and the role of factor XIII in human pathology]

Area of Science:

• Molecular biology and medicine
• Biochemistry
• Hematology

Context:

• The coagulation system is complex, with components like Factor XIII contributing to overall hemostasis.
• Modern molecular biology and medical advancements continually enhance our understanding of coagulation.
• Factor XIII's role extends beyond simple clot formation, impacting various biochemical reactions.

Purpose:

• To present current data on Factor XIII (fibrin stabilizing factor).
• To detail the enzyme's structure, functions, and detection methods.
• To elucidate the role of Factor XIII in the genesis of bleeding and thrombosis.

Summary:

• Factor XIII is essential for stabilizing fibrin clots, a critical step in hemostasis.
• Advances in detection methods have improved knowledge of Factor XIII's involvement in hemostasis.
• Deficiencies and increased activity of Factor XIII are linked to bleeding and thrombotic conditions.

Impact:

• Improved diagnostic capabilities for Factor XIII related disorders.
• Enhanced understanding of bleeding and thrombosis pathogenesis.
• Potential for targeted therapeutic strategies for coagulation factor deficiencies.