Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Arginase-1 and Mer Tyrosine Kinase Expression in Monocyte Populations in Patients with Axial Spondyloarthritis.

Bulletin of experimental biology and medicine·2025

Same author

The Efficacy and Safety of BCD-180, an Anti-TRBV9+ T cell Monoclonal Antibody, in Patients with Active Radiographic Axial Spondyloarthritis: 36-week Results from the Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Study ELEFTA.

Doklady. Biochemistry and biophysics·2025

Same author

Expression of Types I and III Collagens and Ultrastructure of the Extracellular Matrix in Rectal Adenocarcinoma of Different Differentiation Degree after Neoadjuvant Radiation Therapy.

Bulletin of experimental biology and medicine·2024

Same author

Efficacy and Safety of Levilimab in Combination with Methotrexate in Patients with Active Rheumatoid Arthritis: 56-Week Results of Phase III Randomized Double-Blind Placebo-Controlled Trial SOLAR.

Doklady. Biochemistry and biophysics·2024

Same author

Polymorphism of angiogenesis regulation factor genes (VEGF/VEGFR), and extracellular matrix remodeling genes (MMP/TIMP), and the levels of their products in extracellular tissues of patients with primary and secondary lymphedema.

Vavilovskii zhurnal genetiki i selektsii·2024

Same author

Results of a 12-Week Open-Label, Non-Interventional Study of the Efficacy and Safety of Olokizumab Therapy in Patients with Rheumatoid Arthritis after Switching from Anti-B-Cell Therapy during the SARS-CoV-2 Pandemic.

Doklady. Biochemistry and biophysics·2024

Search research articles

Related Experiment Video

Updated: Jul 12, 2025

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

Published on: August 21, 2020

Lithium-Modified Sorbent: Effects on Hemostatic Responses In Vitro.

L N Rachkovskaya¹, A P Momot², A A Smagin¹

¹Research Institute of Clinical and Experimental Lymphology - Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

Bulletin of Experimental Biology and Medicine

|October 20, 2023

Summary

A new lithium-modified sorbent (Al2O3@PDMS/Li) shows reduced blood clotting effects compared to a lithium-free version. This sorbent is less reactive, causing fewer platelet reductions and less hypercoagulation during hemosorption.

Keywords:

aluminum oxide hemocoagulation lithium modified hemosorbent polydimethylsiloxane

More Related Videos

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Published on: March 5, 2020

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

Related Experiment Videos

Last Updated: Jul 12, 2025

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

Published on: August 21, 2020

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Published on: March 5, 2020

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

Area of Science:

Biomaterials Science
Hematology
Medical Device Engineering

Background:

Hemosorption is a blood purification technique.
Sorbents used in hemosorption can interact with blood components, potentially affecting coagulation.
Developing biocompatible sorbents with minimal adverse effects is crucial for patient safety.

Purpose of the Study:

To compare the in vitro effects of a lithium-modified sorbent (Al2O3@PDMS/Li) and a lithium-free sorbent (Al2O3@PDMS) on blood clotting indicators.
To evaluate the reactogenicity and impact on coagulation parameters of the two sorbent types.

Main Methods:

In vitro comparison of two sorbent materials: aluminum oxide and polydimethylsiloxane based, one lithium-modified (Al2O3@PDMS/Li) and one lithium-free (Al2O3@PDMS).
Assessment of blood clotting indicators including platelet count and chronometric parameters.
Thromboelastometry was used to evaluate blood clot density characteristics.

Main Results:

The lithium-modified sorbent (Al2O3@PDMS/Li) exhibited a significantly lower reactogenic effect on blood compared to the lithium-free sorbent.
Platelet reduction was significantly lower with Al2O3@PDMS/Li (19×10^9/L) versus Al2O3@PDMS (66×10^9/L).
Al2O3@PDMS/Li showed a less pronounced hypercoagulation shift and reduced fibrinogen concentration, without affecting clot density parameters.

Conclusions:

Lithium modification of the Al2O3@PDMS sorbent enhances biocompatibility by reducing adverse effects on blood coagulation.
The Al2O3@PDMS/Li sorbent demonstrates potential for safer hemosorption applications due to its reduced impact on platelets and fibrinogen.
Further in vivo studies are warranted to confirm the hemostatic safety and efficacy of this modified sorbent.