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Histopathological variation in keratoconus.

M W Scroggs1, A D Proia

  • 1Department of Pathology, Duke University Medical Center, Durham, North Carolina.

Cornea
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

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Two histopathologic variants of keratoconus were identified, differing in Bowman's layer and epithelial appearance. These variants, typical and atypical keratoconus, suggest a single underlying disease process.

Area of Science:

  • Ophthalmology
  • Histopathology

Background:

  • Keratoconus is a progressive thinning of the cornea.
  • Histopathologic examination of corneal specimens provides insights into disease mechanisms.

Purpose of the Study:

  • To identify and characterize distinct histopathologic variants of keratoconus.
  • To investigate the relationship between these variants and patient demographics.

Main Methods:

  • Analysis of 131 penetrating keratoplasty specimens from patients with keratoconus over 11 years.
  • Histopathologic evaluation of Bowman's layer and corneal epithelium.
  • Demographic data analysis, including race and surgical history.

Main Results:

  • Two variants identified: "typical" (breaks in Bowman's layer, epithelial thinning) and "atypical" (no breaks, less thinning).

Related Experiment Videos

  • Both variants showed similar central stromal thinning.
  • Atypical variant was more prevalent in white individuals (95%) compared to typical (49%).
  • Histologic concordance was observed in 72% of bilateral keratoplasty pairs.

    • Conclusions:

    • "Typical" and "atypical" keratoconus variants represent manifestations of the same disease.
    • Race may be a demographic factor associated with keratoconus variants.