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Related Experiment Videos

Improved detection of microbubble signals using power M-mode Doppler.

Maher Saqqur1, Naeem Dean, Marcia Schebel

  • 1Department of Medicine (Neurology), University of Calgary, Calgary, Alberta, Canada.

Stroke
|December 20, 2003
PubMed
Summary

Power motion-mode transcranial Doppler (TCD) is a new technique that enhances embolus detection. This study found PMD TCD identifies more microbubble signals (MBS) than spectral TCD, especially in the ACA and MCA.

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Area of Science:

  • Neurology
  • Medical Imaging
  • Vascular Ultrasound

Background:

  • Power motion-mode transcranial Doppler (TCD) is a novel multigated ultrasound technique.
  • It offers potential for simplified and enhanced detection of emboli.
  • This study developed and validated criteria for emboli detection using PMD.

Purpose of the Study:

  • To develop and validate novel criteria for detecting emboli using power motion-mode transcranial Doppler (PMD).
  • To compare the diagnostic performance of PMD TCD with conventional spectral TCD for microemboli detection in patients with right-to-left shunts.

Main Methods:

  • Thirty-six patients with confirmed right-to-left shunts underwent both spectral TCD and PMD TCD bubble studies.
  • Novel PMD criteria were established, including signal intensity, motion characteristics, and depth.

Related Experiment Videos

  • Studies were blindly assessed for microbubble signal (MBS) counts in the middle cerebral arteries (MCA) and anterior cerebral arteries (ACA).

    • Main Results:

    • Median MBS counts in the MCA were 4 for both spectral TCD and PMD TCD.
    • High correlations were observed between spectral TCD and PMD TCD for MCA (rho=0.97) and ACA (rho=0.79) emboli detection.
    • A significant 2-fold increase in total MBS counts was detected by PMD TCD compared to spectral TCD when summing ACA and MCA findings (P<0.001).

    Conclusions:

    • Power motion-mode transcranial Doppler (PMD TCD) detects a higher number of microbubble signals (MBS) compared to spectral TCD.
    • PMD TCD enhances emboli detection by identifying signals in both the anterior and middle cerebral arteries.
    • Adherence to specific criteria can prevent overcounting of emboli with PMD TCD.