Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction
Alan G Sutherland1, Juan Alvarez, Weidong Ding
1Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA. sutherag@wyeth.com
Abstract:
Structural features of two weak inhibitors of the ZipA-FtsZ protein-protein interaction which were found to bind to overlapping but different areas of the key binding site were combined in one new series of carboxybiphenyl-indoles with improved inhibitory activity.
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