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Updated: Aug 29, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

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Published on: March 24, 2015

Interferon in the treatment of cutaneous T-cell lymphoma

Elise A Olsen1

  • 1Division of Dermatology, CTCL Clinic and Research Center, Duke University, Durham, North Carolina 27710, USA. olsen001@mc.duke.edu

Dermatologic Therapy
|December 23, 2003
PubMed

Interferons are polypeptides with a broad range of in vivo effects that have shown efficacy in cutaneous T-cell lymphoma (CTCL). Particularly useful is alfa interferon (IFN) which, as a single agent, has shown partial remission rates of > 50% and complete responses of > 20%. Side-effects are predictable, generally well tolerated and dose-related. The efficacy of IFN has increased with combination therapy without any significant increase in attendant side-effects. An update on the specifics of the different IFN subtypes, their inherent biologic activity, pharmacokinetics, efficacy and safety in CTCL is presented in this paper.

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