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The measurement and interpretation of age-specific vaccine efficacy
1Communicable Disease Surveillance Centre, London, UK.
International Journal of Epidemiology
|October 1, 1992
Abstract:
The age-specific efficacy of a vaccine depends upon the mechanism of vaccine action and the force of infection in the unvaccinated subpopulation. Consequently, inferences concerning the persistence of vaccine-induced immunity cannot in general be made directly from age-specific vaccine efficacy estimates. The definition, estimation and interpretation of age-specific vaccine efficacy measures are discussed using simple models of vaccine action. The methods are applied to data on measles and pertussis vaccines.