The march toward rational therapeutics in children

Although children suffer from many of the same diseases as adults, the majority of drugs are not approved for pediatric use. This places children at risk, either that they will not be treated adequately because of the lack of approved agents or that their physician will be lacking the necessary labeling information to treat appropriately with a given agent. This paper details the slow progress over the last 25 years toward providing pediatric labeling and thus providing children with optimal protection and range of treatment options.