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HCV and HGV infection in Hodgkin's disease

Katalin Keresztes1, Mária Takács, Margit Horányi

  • 13rd Department of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, H-4004, Hungary. katalin@iiibel.dote.hu

Pathology Oncology Research : POR
|December 23, 2003
PubMed

Insights

Hepatitis C virus (HCV) and hepatitis G virus (HGV) infections were more common in Hodgkin

Area of Science:

  • Virology
  • Oncology
  • Epidemiology

Background:

  • Malignant lymphomas, including Hodgkin's disease, are multifactorial in pathogenesis.
  • Viruses are suspected as potential etiologic agents in Hodgkin's disease.
  • Epstein-Barr virus is a known factor, but other viruses may also be involved.

Purpose of the Study:

  • To investigate the prevalence of hepatitis C virus (HCV) and hepatitis G virus (HGV) in patients with Hodgkin's disease.
  • To compare HCV and HGV infection rates in Hodgkin's disease patients with those in the general Hungarian blood donor population.

Main Methods:

  • Polymerase chain reaction (PCR) was used to detect HCV and HGV in 111 randomly selected Hodgkin's disease patients.
  • Infection rates were compared to data from the Hungarian blood bank using PCR.

Main Results:

  • HCV was detected in 9% of patients and HGV in 8.1% of patients.
  • HCV infection rates were 12-fold higher, and HGV rates were 1.5-fold higher in patients compared to blood donors.
  • No significant differences were observed between hepatitis-positive and negative patients regarding age, sex, disease stage, histology, treatment, risk factors, or liver enzymes.

Conclusions:

  • Hepatitis C virus positivity is significantly higher in Hodgkin's disease patients than in blood donors.
  • The etiological role of HCV and HGV in Hodgkin's disease remains inconclusive.
  • Further research is necessary to elucidate the viral contribution to Hodgkin's disease pathogenesis.

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