Related Experiment Video
Updated: Aug 29, 2026

Analysis of Cell Cycle Position in Mammalian Cells
Published on: January 21, 2012
HCMV infection: modulating the cell cycle and cell death
Jonathan P Castillo1, Timothy F Kowalik
1Program in Immunology and Virology, Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Abstract:
Human cytomegalovirus (HCMV) is a member of the Herpesviridae family and is recognized as a significant pathogen to certain subgroups of the human population. It has become apparent that HCMV manipulation of the host cell cycle as well as the immune response promotes the replication and propagation of the virus. The ability of HCMV to modulate components of the host immune system and the response to infection most likely contributes to the pathology associated with this virus. This review will address the mechanisms HCMV has adapted to modulate the cell cycle to promote viral replication as well as the different ways it can prevent the "death" of an infected cell.
Related Concept Videos
Cytomegalovirus Disease
Inhibition of Cdk Activity
Molecular Factors Affecting Cell Division
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Regulation of Hematopoietic Stem Cells
The Cell Cycle Control System
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
Positive Regulator Molecules

