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Minocycline-induced Sweet's syndrome
M J Thibault1, R C Billick, H Srolovitz
1Department of Dermatology and Pathology, Jewish General Hospital, University of McGill, Montreal, Quebec, Canada.
Journal of the American Academy of Dermatology
|November 1, 1992
Summary
Minocycline can cause Sweet's syndrome, a rare skin reaction. This case highlights the importance of recognizing this adverse drug effect for prompt treatment.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Sweet's syndrome is an acute febrile neutrophilic dermatosis.
- Drug-induced Sweet's syndrome is a recognized but uncommon phenomenon.
Observation:
- A 32-year-old male developed symptoms 10 days after starting minocycline for acne.
- The patient presented with clinical features consistent with Sweet's syndrome.
Findings:
- This is the second reported case of minocycline-induced Sweet's syndrome.
- It is the first such case reported in the American literature.
- The condition resolved rapidly upon minocycline withdrawal and initiation of oral prednisone.
Implications:
- Clinicians should consider minocycline as a potential cause of Sweet's syndrome.
- Early recognition and management are crucial for favorable outcomes.
- This case expands the understanding of adverse reactions to minocycline therapy.